Michael Rutenberg

Michael Rutenberg, M.D., Ph.D.

CLIN ASO PROF

Department: MD-RADIATION ONCOLOGY
Business Phone: (904) 588-1246
Business Email: mrut@ufl.edu

About Michael Rutenberg

Dr. Rutenberg is an Assistant Professor of Radiation Oncology. He specializes in the care of patients with malignancies of the gastrointestinal and central nervous systems and sarcomas. He leads the reirradiation program at the UF Health Proton Therapy Institute, utilizing proton therapy for patients previously treated with radiotherapy. His research interests include esophageal and liver cancers, sarcoma, brain and spine malignancies. Dr. Rutenberg has published his research in peer-reviewed medical journals including International Journal of Radiation Oncology Biology Physics, Practical Radiation Oncology, Molecular Cell, and Nature.

An alumnus of the University of Florida’s MD/PhD program, Dr. Rutenberg completed medical school at UF and conducted his PhD research at Harvard Medical School. He spent four years in the radiation oncology residency program at the University of Maryland Medical Center and was named chief resident and received the Radiological Society of North America Resident Research Award. He has served on the ASTRO Radiation and Cancer Biology Committee of the Science Council. He is the Chair of the Proton Collaborative Group Reirradiation Subcommittee and serves on the NRG Brain Tumor Core Committee.

Clinical Profile

Specialties
  • Radiation Oncology
Areas of Interest
  • Esophageal cancer
  • Pancreatic cancer

Publications

2021
Clinical Outcomes Following Dose-Escalated Proton Therapy for Skull-Base Chordoma.
International journal of particle therapy. 8(1):179-188 [DOI] 10.14338/IJPT-20-00066.1. [PMID] 34285945.
2021
Correction to: Clinical outcomes following proton therapy for adult craniopharyngioma: a single‑institution cohort study.
Journal of neuro-oncology. 152(2) [DOI] 10.1007/s11060-021-03740-8. [PMID] 33751336.
2021
Correction to: Proton therapy for adult medulloblastoma: Acute toxicity and disease control outcomes.
Journal of neuro-oncology. 153(3) [DOI] 10.1007/s11060-021-03798-4. [PMID] 34196917.
2021
Current Management and Image Review of Skull Base Chordoma: What the Radiologist Needs to Know.
Journal of clinical imaging science. 11 [DOI] 10.25259/JCIS_139_2021. [PMID] 34513210.
2021
Evaluation of head and neck soft tissue sarcoma 8th edition pathologic staging system and proposal of a novel stage grouping system.
Oral oncology. 114 [DOI] 10.1016/j.oraloncology.2020.105137. [PMID] 33422859.
2021
Proton therapy for adult medulloblastoma: Acute toxicity and disease control outcomes.
Journal of neuro-oncology. 153(3):467-476 [DOI] 10.1007/s11060-021-03783-x. [PMID] 34105033.
2021
The Role of Radiation Therapy for Symptomatic Desmoid Tumors.
Current treatment options in oncology. 22(4) [DOI] 10.1007/s11864-021-00831-6. [PMID] 33649873.
2021
Vision loss following high-dose proton-based radiotherapy for skull-base chordoma and chondrosarcoma.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 158:125-130 [DOI] 10.1016/j.radonc.2021.02.012. [PMID] 33610625.
2020
Clinical outcomes following proton therapy for adult craniopharyngioma: a single-institution cohort study.
Journal of neuro-oncology. 147(2):387-395 [DOI] 10.1007/s11060-020-03432-9. [PMID] 32086697.
2020
Proton beam radiotherapy for pancreas cancer.
Journal of gastrointestinal oncology. 11(1):166-175 [DOI] 10.21037/jgo.2019.03.02. [PMID] 32175120.
2020
Using Robust Optimization for Skin Flashing in Intensity Modulated Radiation Therapy for Breast Cancer Treatment: A Feasibility Study.
Practical radiation oncology. 10(1):59-69 [DOI] 10.1016/j.prro.2019.09.017. [PMID] 31627030.
2019
A comprehensive dosimetric study of Monte Carlo and pencil-beam algorithms on intensity-modulated proton therapy for breast cancer.
Journal of applied clinical medical physics. 20(1):128-136 [DOI] 10.1002/acm2.12497. [PMID] 30488548.
2019
Can CT imaging improve targeting accuracy in clip-based proton therapy of ocular melanoma?
Physics in medicine and biology. 64(3) [DOI] 10.1088/1361-6560/aaf9c9. [PMID] 30566923.
2019
Clinical Outcomes of Patients With Recurrent Lung Cancer Reirradiated With Proton Therapy on the Proton Collaborative Group and University of Florida Proton Therapy Institute Prospective Registry Studies.
Practical radiation oncology. 9(4):280-288 [DOI] 10.1016/j.prro.2019.02.008. [PMID] 30802618.
2019
Multidisciplinary Imaging Review Conference Improves Neuro-oncology Radiation Treatment Planning and Follow-up.
Cureus. 11(10) [DOI] 10.7759/cureus.5882. [PMID] 31772852.
2019
Optimizing neoadjuvant radiotherapy for resectable and borderline resectable pancreatic cancer using protons.
World journal of gastrointestinal surgery. 11(7):303-307 [DOI] 10.4240/wjgs.v11.i7.303. [PMID] 31602289.
2019
Proton therapy for skull base tumors: A review of clinical outcomes for chordomas and chondrosarcomas.
Head & neck. 41(2):536-541 [DOI] 10.1002/hed.25479. [PMID] 30537295.
2019
Proton therapy for skull-base chondrosarcoma, a single-institution outcomes study.
Journal of neuro-oncology. 142(3):557-563 [DOI] 10.1007/s11060-019-03129-8. [PMID] 30827010.
2019
The impact of dose algorithms on tumor control probability in intensity-modulated proton therapy for breast cancer.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB). 61:52-57 [DOI] 10.1016/j.ejmp.2019.04.011. [PMID] 31151579.
2018
Long-Term Outcomes of Fractionated Stereotactic Proton Therapy for Vestibular Schwannoma: A Case Series.
International journal of particle therapy. 4(4):37-46 [DOI] 10.14338/IJPT-17-00032.1. [PMID] 31773014.
2018
Patterns of Failure in Patients With Adult Medulloblastoma Presenting Without Extraneural Metastasis.
American journal of clinical oncology. 41(10):1015-1018 [DOI] 10.1097/COC.0000000000000407. [PMID] 29045264.
2018
Pencil beam scanning versus passively scattered proton therapy for unresectable pancreatic cancer.
Journal of gastrointestinal oncology. 9(4):687-693 [DOI] 10.21037/jgo.2018.03.14. [PMID] 30151265.
2018
Prognostic factors of radiation dermatitis following passive-scattering proton therapy for breast cancer.
Radiation oncology (London, England). 13(1) [DOI] 10.1186/s13014-018-1004-3. [PMID] 29673384.
2018
Radiation Therapy for Aggressive Fibromatosis: The Association Between Local Control and Age.
International journal of radiation oncology, biology, physics. 100(4):997-1003 [DOI] 10.1016/j.ijrobp.2017.12.259. [PMID] 29485080.
2017
A Technical Guide for Passive Scattering Proton Radiation Therapy for Breast Cancer.
International journal of particle therapy. 3(4):473-484 [DOI] 10.14338/IJPT-16-00025.1. [PMID] 31772997.
2017
Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer.
World journal of gastrointestinal surgery. 9(4):103-108 [DOI] 10.4240/wjgs.v9.i4.103. [PMID] 28503258.
2016
A Prospective Evaluation of Acute Toxicity from Proton Therapy for Targets of the Parotid Region.
International journal of particle therapy. 3(2):285-290 [DOI] 10.14338/IJPT-16-00010.2. [PMID] 31772979.
2016
Initial Report of a Prospective Dosimetric and Clinical Feasibility Trial Demonstrates the Potential of Protons to Increase the Therapeutic Ratio in Breast Cancer Compared With Photons.
International journal of radiation oncology, biology, physics. 95(1):411-421 [DOI] 10.1016/j.ijrobp.2015.09.018. [PMID] 26611875.
2016
Salvage external beam radiotherapy for locally recurrent prostate cancer after definitive brachytherapy.
Brachytherapy. 15(6):722-729 [DOI] 10.1016/j.brachy.2016.08.004. [PMID] 27693225.
2015
Proton therapy for pancreatic cancer.
World journal of gastrointestinal oncology. 7(9):141-7 [DOI] 10.4251/wjgo.v7.i9.141. [PMID] 26380057.
2014
Proton therapy for Hodgkin lymphoma.
Current hematologic malignancy reports. 9(3):203-11 [DOI] 10.1007/s11899-014-0212-7. [PMID] 24842407.
2013
LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation.
Molecular cell. 49(3):558-70 [DOI] 10.1016/j.molcel.2012.11.019. [PMID] 23260659.
2013
Radiation therapy for sinonasal inverted papilloma.
Practical radiation oncology. 3(4):275-81 [DOI] 10.1016/j.prro.2012.07.007. [PMID] 24674398.
2011
External-Beam Radiotherapy for Inverted Papillomas of the Nasal Cavity and Paranasal Sinuses: the University of Florida Experience
International Journal of Radiation Oncology Biology Physics. 81
2011
External-beam radiotherapy for pediatric and young adult desmoid tumors.
Pediatric blood & cancer. 57(3):435-42 [DOI] 10.1002/pbc.22916. [PMID] 21744472.
2010
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.
Molecular cell. 39(2):222-33 [DOI] 10.1016/j.molcel.2010.07.008. [PMID] 20670891.
2008
Serial Kilovoltage Cone-Beam Computed Tomography Imaging During Intensity Modulated Radiotherapy for Primary Lung Cancers: Observations of Treatment Effect and Tumor-Volume Regression
International Journal of Radiation Oncology Biology Physics. 72(1) [DOI] 10.1016/j.ijrobp.2008.06.1354.
2007
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.
Nature. 447(7144):601-5 [PMID] 17468742.
View on: PubMed
2004
Cell fusion and reprogramming: resolving our transdifferences.
Trends in molecular medicine. 10(3):93-6 [PMID] 15106589.
View on: PubMed
2004
Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets.
The Journal of clinical endocrinology and metabolism. 89(4):1641-5 [PMID] 15070924.
View on: PubMed
2004
Stem cell plasticity, beyond alchemy.
International journal of hematology. 79(1):15-21 [PMID] 14979473.
View on: PubMed
1986
Osteoarthritis of the hand and osteoporosis.
Clinical orthopaedics and related research. (203):239-43 [PMID] 3955985.
View on: PubMed
1982
Osteoarthritis of the hip joint and osteoporosis: a radiological study in a random population sample in Jerusalem.
Clinical orthopaedics and related research. (164):130-5 [PMID] 7067275.
View on: PubMed

Grants

Mar 2019 ACTIVE
RANDOMIZED PHASE II TRIAL OF HYPOFRACTIONATED DOSE-ESCALATED PHOTON IMRT OR PROTON BEAM THERAPY VERSUS CONVENTIONAL PHOTON IRRADIATION WITH CONCOMITANT AND ADJUVANT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
Role: Principal Investigator
Funding: NRG ONCOLOGY FOU via NATL INST OF HLTH NCI
Mar 2014 – Feb 2019
NRG-BN001 – Randomized Phase II Trial of Hypodrationated Dose-Escalated Photon IMRT or Proton Bean Therapy Versus Conventional Photon Irradiation With Concomitant and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma.
Role: Principal Investigator
Funding: NRG ONCOLOGY FOU via NATL INST OF HLTH NCI

Education

Other program – Radiation Oncology
2014 · St. Jude Children's Research Hospital
Residency – Radiation Oncology
2014 · University of Maryland
Other program – Radiation Oncology
2013 · University of Florida
Internship – Internal Medicine
2010 · University of Florida
Medical Degree
2009 · University of Florida
Doctoral Degree
2007 · University of Florida
Bachelor's Degree
1998 · University of Florida

Contact Details

Phones:
Business:
(904) 588-1246
Emails:
Business:
mrut@ufl.edu