Dominick J Angiolillo, M.D., Ph.D.
Professor; Chief, Division Of Cardiology; Medical Director, UF Health Cardiovascular Center – Jacksonville; Medical Director, Cardiovascular Research Program; Program Director, Interventional Cardiology Fellowship
Department:
Medicine – Jacksonville
Business Phone:
(904) 244-2655
Business Email:
dominick.angiolillo@jax.ufl.edu
About Dominick J Angiolillo
Dominick J. Angiolillo, M.D., Ph.D., is Chief of the Division of Cardiology and Medical Director of the UF Health Cardiovascular Center. Dr. Angiolillo graduated summa cum laude from the Catholic University of the Sacred Heart Medical School in Rome, Italy, where he completed training in medicine and cardiology. He then pursued training in interventional cardiology at the Complutense University of Madrid in Spain and received his Ph.D. in cellular and molecular cardiology. In 2004, Dr. Angiolillo joined the University of Florida College of Medicine – Jacksonville, where he is a professor of medicine with tenure status, director of cardiovascular research and director of the interventional cardiology fellowship program. He is staff cardiologist and interventional cardiologist on the UF Health Jacksonville campus. Dr. Angiolillo is board-certified in cardiovascular disease and interventional cardiology.
Much of Dr. Angiolillo’s professional career has been devoted to cardiovascular research in the field of interventional cardiology and acute coronary syndrome. His largest national and international recognition has been for his pivotal contributions in the field of thrombosis. In particular, Dr. Angiolillo has performed seminal studies on platelet function and modulation of antiplatelet drug response, including genetic studies. He has received national and international academic recognitions for this work. Recognitions include the 2013 Outstanding Achievement Award from the European Society of Cardiology and, since 2014, Dr. Angiolillo has been in the top 1 percent of most-cited researchers worldwide, according to Clarivate Analytics. Dr. Angiolillo has been a key investigator in the clinical development of numerous novel antithrombotic agents. He works alongside drug-regulating agencies in the United States and Europe toward approval of these drugs and product labeling updates. His success in obtaining extramural funding has allowed the development of one of the most active clinical research centers in the U.S. as well as one of the leading centers for thrombosis research in the world.
Dr. Angiolillo has made major scientific contributions to many medical and cardiovascular journals, as well as cardiovascular medicine textbooks. He has authored more than 650 peer-reviewed articles, with over 60,000 citations and an H-index of 107. He has authored more than 35 book chapters and is the editor of his own textbook on antithrombotic medicine. Due to his major contributions in antithrombotic therapy in patients with cardiovascular disease manifestations, Dr. Angiolillo has been invited to deliver lectures worldwide. His international visibility has allowed him to develop a very active research training program, attracting physicians and scientists from across the globe. In addition, Dr. Angiolillo has been a clinical mentor for years to residents and fellows, resulting in several Exemplary Teacher Awards. His leadership role as an academic clinician and scientist allows to him to nurture and promote career growth of many young trainees in the United States and abroad.
Dr. Angiolillo is an active member of many cardiovascular societies in the U.S. and Europe. In addition, he serves on the editorial board of numerous cardiovascular journals, some of which he holds leadership roles. He is a scientific reviewer for many major journals and extramural funding agencies, including the National Institutes of Health and other federal funding agencies in several European countries.
Additional Positions:
Chief
2021 – Current
·
UF Division of Cardiology – Jacksonville
Medical Director
2021 – Current
·
UF Health Cardiovascular Center
Professor
2015 – Current
·
University of Florida
Program Director
2015 – Current
·
Interventional Cardiology Fellowship
Medical Director
2010 – Current
·
Cardiovascular Research Program
Related Links:
Accomplishments
Highly Cited Researchers
2020
·
Clarivate
10-Year Service Pin
2018
·
University of Florida College of Medicine – Jacksonville
Highly Cited Researchers
2018
·
Clarivate
Highly Cited Researchers
2017
·
Clarivate
University of Florida Research Foundation Professorship
2017
·
University of Florida
Cardiovascular Disease Exam Committee
2016
·
American Board of Internal Medicine
Simon Dack Award for Outstanding Scholarship
2016
·
American College of Cardiology
The World’s Most Influential Scientific Minds
2016
·
Thomas Reuters
Simon Dack Award for Outstanding Scholarship
2015
·
American College of Cardiology
Outstanding Achievement Award
2013
·
European Society of Cardiology
Board Certifications
-
Cardiovascular DiseaseAmerican Board of Internal Medicine
-
Interventional CardiologyAmerican Board of Internal Medicine
Clinical Profile
Specialties
- Internal Medicine
Subspecialties
- Cardiology
- Interventional Cardiology
Areas of Interest
- Acute coronary syndrome
- Angioplasty and stent placement – heart
- Cardiac catheterization
- Cardiac intravascular ultrasound
- Coronary heart disease
- Deep vein thrombosis
- Heart and vascular services
- Heart attack
- Heart disease
- Heparin coated coronary artery stent
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0001-8451-2131
Publications
2024
1- Versus 3-Month DAPT in Older Patients at a High Bleeding Risk Undergoing PCI: Insights from the XIENCE Short DAPT Global Program.
The American journal of cardiology.
214:94-104
[DOI] 10.1016/j.amjcard.2023.12.049.
[PMID] 38185438.
2024
Antacid Therapy in Coronary Artery Disease and Heart Failure: Proton Pump Inhibitors vs. H2 Receptor Blockers.
Cardiovascular drugs and therapy.
38(1):181-189
[DOI] 10.1007/s10557-022-07358-4.
[PMID] 35715526.
2024
Antithrombotic therapy in patients with acute coronary syndrome: similarities and differences between a European expert consensus document and the 2023 European Society of Cardiology guidelines.
European heart journal. Acute cardiovascular care.
13(1):173-180
[DOI] 10.1093/ehjacc/zuad158.
[PMID] 38170562.
2024
Aspirin hypersensitivity and intolerance.
European heart journal. Cardiovascular pharmacotherapy.
[DOI] 10.1093/ehjcvp/pvae008.
[PMID] 38268418.
2024
Impact of ethnicity on antiplatelet treatment regimens for bleeding reduction in acute coronary syndromes: a systematic review and pre-specified subgroup meta-analysis.
European heart journal. Cardiovascular pharmacotherapy.
10(2):158-169
[DOI] 10.1093/ehjcvp/pvad085.
[PMID] 37960983.
2024
Long-term survival after cardiac arrest in patients undergoing emergent coronary angiography.
Cardiovascular revascularization medicine : including molecular interventions.
60:18-26
[DOI] 10.1016/j.carrev.2023.09.008.
[PMID] 37793964.
2024
Nonadherence to dual antiplatelet therapy: old problems without new solutions.
Revista espanola de cardiologia (English ed.).
77(2):125-128
[DOI] 10.1016/j.rec.2023.08.003.
[PMID] 37659651.
2024
North American perspective on the 2023 European Society of Cardiology guidelines for the management of acute coronary syndromes
European Heart Journal: Acute Cardiovascular Care.
13(1):165-172
[DOI] 10.1093/ehjacc/zuad153.
2024
One-month DAPT with ticagrelor and aspirin for patients undergoing coronary artery bypass grafting: rationale and design of the randomised, multicentre, double-blind, placebo-controlled ODIN trial.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
20(5):e322-e328
[DOI] 10.4244/EIJ-D-23-00699.
[PMID] 38436365.
2024
Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease
Nature Reviews Cardiology.
[DOI] 10.1038/s41569-024-01003-3.
2024
Optimizing LDL-cholesterol management in ACS patients: Breaking inertia and implementing intensified therapies.
International journal of cardiology.
400
[DOI] 10.1016/j.ijcard.2024.131803.
[PMID] 38262483.
2024
Prehospital crushed versus integral prasugrel loading dose in STEMI patients with a large myocardial area.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
20(7):e436-e444
[DOI] 10.4244/EIJ-D-23-00618.
[PMID] 38562070.
2024
Reply: Decoding Ticagrelor Dyspnea: Central Apnea Screening Before Drug Discontinuation.
JACC. Cardiovascular interventions.
17(3):452-453
[DOI] 10.1016/j.jcin.2023.12.035.
[PMID] 38355276.
2024
Role of the P2Y12 receptor on thrombus formation and evolution in therapeutic strategies.
Expert opinion on therapeutic targets.
28(1-2):5-8
[DOI] 10.1080/14728222.2024.2315017.
[PMID] 38315098.
2024
Switching from Dual Antiplatelet Therapy with Aspirin Plus a P2Y12 Inhibitor to Dual Pathway Inhibition with Aspirin Plus Vascular-Dose Rivaroxaban: The Switching Anti-Platelet and Anti-Coagulant Therapy (SWAP-AC) Study
Thrombosis and Haemostasis.
124(3):263-273
[DOI] 10.1055/a-2098-6639.
2024
The Lipid–Platelet Interplay: Unraveling the Effects of PCSK9 Inhibition on Platelet Reactivity
Thrombosis and Haemostasis.
[DOI] 10.1055/s-0044-1782161.
2024
Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis.
JAMA cardiology.
[DOI] 10.1001/jamacardio.2024.0133.
[PMID] 38506796.
2024
Ticagrelor with or without aspirin following percutaneous coronary intervention in high-risk patients with concomitant peripheral artery disease: A subgroup analysis of the TWILIGHT randomized clinical trial.
American heart journal.
272:11-22
[DOI] 10.1016/j.ahj.2024.03.002.
[PMID] 38458371.
2024
When Direct Oral Anticoagulants Should Not Be Standard Treatment: JACC State-of-the-Art Review.
Journal of the American College of Cardiology.
83(3):444-465
[DOI] 10.1016/j.jacc.2023.10.038.
[PMID] 38233019.
2023
1- or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After PCI.
JACC. Cardiovascular interventions.
16(20):2498-2510
[DOI] 10.1016/j.jcin.2023.08.014.
[PMID] 37804290.
2023
Adjusted mortality of extracorporeal membrane oxygenation for acute myocardial infarction patients in cardiogenic shock.
Medicine.
102(11)
[DOI] 10.1097/MD.0000000000033221.
[PMID] 36930119.
2023
Advances in the available pharmacotherapy for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Expert Opinion on Pharmacotherapy.
24(4):453-471
[DOI] 10.1080/14656566.2023.2171788.
2023
Antithrombotic Therapy in Arterial Thrombosis and Thromboembolism in COVID-19: An American College of Chest Physicians Expert Panel Report.
Chest.
164(6):1531-1550
[DOI] 10.1016/j.chest.2023.06.032.
[PMID] 37392958.
2023
Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease.
European heart journal. Cardiovascular pharmacotherapy.
9(5):462-496
[DOI] 10.1093/ehjcvp/pvad032.
[PMID] 37120728.
2023
Association between Platelet Count and Treatment Effect of Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
Thrombosis and Haemostasis.
123(4):464-477
[DOI] 10.1055/a-1988-5047.
[PMID] 36442805.
2023
Author Correction: Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Nature Reviews Cardiology.
[DOI] 10.1038/s41569-023-00974-z.
2023
Biolimus-eluting vs. other limus-eluting stents in NSTE-ACS: A pooled analysis of GLASSY and TWILIGHT.
International journal of cardiology.
383:24-32
[DOI] 10.1016/j.ijcard.2023.04.027.
[PMID] 37080466.
2023
Bivalirudin in acute coronary syndromes
Expert Review of Cardiovascular Therapy.
21(12):901-911
[DOI] 10.1080/14779072.2023.2273902.
2023
Bivalirudin plus a high-dose infusion versus heparin in patients with acute coronary syndrome.
European heart journal. Cardiovascular pharmacotherapy.
9(7):666-668
[DOI] 10.1093/ehjcvp/pvad029.
[PMID] 37081774.
2023
Bleeding and Ischemic Risks of Ticagrelor Monotherapy After Coronary Interventions.
Journal of the American College of Cardiology.
82(8):687-700
[DOI] 10.1016/j.jacc.2023.05.062.
[PMID] 37587580.
2023
Bleeding in acute coronary syndrome: from definitions, incidence, and prognosis to prevention and management
Expert Opinion on Drug Safety.
22(12):1193-1212
[DOI] 10.1080/14740338.2023.2291865.
2023
Cangrelor in Patients With Coronary Artery Disease Pretreated With Ticagrelor: The Switching Antiplatelet (SWAP)-5 Study.
JACC. Cardiovascular interventions.
16(1):36-46
[DOI] 10.1016/j.jcin.2022.10.034.
[PMID] 36317958.
2023
Clinical and Pre-Clinical Pharmacokinetics and Pharmacodynamics of Bentracimab.
Clinical pharmacokinetics.
62(5):673-692
[DOI] 10.1007/s40262-023-01245-3.
[PMID] 37118383.
2023
Clinical Pharmacokinetics and Pharmacodynamics of CSL112
Clinical Pharmacokinetics.
62(4):541-558
[DOI] 10.1007/s40262-023-01224-8.
[PMID] 36928983.
2023
Clinically Driven Revascularization in High-Risk Patients Treated With Ticagrelor Monotherapy After PCI: Insights from the Randomized TWILIGHT Trial.
The American journal of cardiology.
208:16-24
[DOI] 10.1016/j.amjcard.2023.09.008.
[PMID] 37806185.
2023
Considerations on the Management of Acute Postoperative Ischemia After Cardiac Surgery: A Scientific Statement From the American Heart Association.
Circulation.
148(5):442-454
[DOI] 10.1161/CIR.0000000000001154.
[PMID] 37345559.
2023
Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Nature Reviews Cardiology.
[DOI] 10.1038/s41569-023-00953-4.
2023
Correction to: Clinical Pharmacokinetics and Pharmacodynamics of CSL112
Clinical Pharmacokinetics.
62(7):1043-1043
[DOI] 10.1007/s40262-023-01277-9.
2023
COVID-19-Associated Pulmonary Embolism: Review of the Pathophysiology, Epidemiology, Prevention, Diagnosis, and Treatment.
Seminars in thrombosis and hemostasis.
49(8):816-832
[DOI] 10.1055/s-0042-1757634.
[PMID] 36223804.
2023
DAPT guided by platelet function tests or genotyping after PCI: pros and cons.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
19(7):546-548
[DOI] 10.4244/EIJ-E-23-00022.
[PMID] 37720965.
2023
Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium
Circulation.
147(25):1933-1944
[DOI] 10.1161/circulationaha.123.064473.
2023
Differences Among Clinical Trials and Registries on Surgical and Percutaneous Coronary Interventions.
The Annals of thoracic surgery.
115(1):79-86
[DOI] 10.1016/j.athoracsur.2022.05.015.
[PMID] 35643330.
2023
Direct Stenting versus Conventional Stenting in Patients with ST-Segment Elevation Myocardial Infarction-A COMPARE CRUSH Sub-Study.
Journal of clinical medicine.
12(20)
[DOI] 10.3390/jcm12206645.
[PMID] 37892785.
2023
Dual pathway inhibition in patients with atherosclerotic disease: pharmacodynamic considerations and clinical implications
Expert Review of Clinical Pharmacology.
16(1):27-38
[DOI] 10.1080/17512433.2023.2154651.
2023
Dyspnea-Related Ticagrelor Discontinuation After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.
16(20):2514-2524
[DOI] 10.1016/j.jcin.2023.08.019.
[PMID] 37879803.
2023
Editorial: Precision medicine for antithrombotic therapy in patients after percutaneous coronary interventions.
Frontiers in cardiovascular medicine.
10
[DOI] 10.3389/fcvm.2023.1162630.
[PMID] 36937928.
2023
Effect of lipid-lowering therapy on platelet reactivity in patients treated with and without antiplatelet therapy.
Minerva cardiology and angiology.
[DOI] 10.23736/S2724-5683.23.06411-6.
[PMID] 37870424.
2023
Efficacy and safety of lidocaine vs. opioid analgesics in acute coronary syndromes
European Heart Journal. Acute Cardiovascular Care.
12(1):12-13
[DOI] 10.1093/ehjacc/zuac157.
2023
European practice patterns for antiplatelet management in NSTE-ACS patients: Results from the REal-world ADoption survey focus on Acute antiPlatelet Treatment (READAPT) survey.
International journal of cardiology.
386:8-16
[DOI] 10.1016/j.ijcard.2023.05.025.
[PMID] 37201617.
2023
Evaluating the pharmacokinetic and pharmacodynamic impact of different modes of ticagrelor administration
Expert Opinion on Drug Metabolism & Toxicology.
19(11):769-784
[DOI] 10.1080/17425255.2023.2272595.
2023
Evaluation of Potential Racial Disparities in CYP2C19-Guided P2Y12 Inhibitor Prescribing After Percutaneous Coronary Intervention.
Clinical pharmacology and therapeutics.
113(3):615-623
[DOI] 10.1002/cpt.2776.
[PMID] 36306392.
2023
External validity of the PRECISE-DAPT score in patients undergoing PCI: a systematic review and meta-analysis.
European heart journal. Cardiovascular pharmacotherapy.
9(8):709-721
[DOI] 10.1093/ehjcvp/pvad063.
[PMID] 37634083.
2023
Factor XI inhibitors in adjunct to antiplatelet therapy: the ultimate dual-pathway inhibition?
Bleeding, Thrombosis, and Vascular Biology.
2(3)
[DOI] 10.4081/btvb.2023.90.
2023
Factor XI Inhibitors in Early Clinical Trials: A Meta-analysis
Thrombosis and Haemostasis.
123(06):576-584
[DOI] 10.1055/a-2043-0346.
2023
Gender differences in efficacy and safety of antiplatelet strategies for acute coronary syndromes
Expert Opinion on Drug Safety.
22(8):669-683
[DOI] 10.1080/14740338.2023.2245331.
2023
How is pharmacogenetics changing clinical trial design for percutaneous coronary intervention?
Expert Review of Clinical Pharmacology.
16(5):383-385
[DOI] 10.1080/17512433.2023.2203381.
2023
Immature Platelet Fraction Predicts Adverse Events in Patients With Acute Coronary Syndrome: the ISAR-REACT 5 Reticulated Platelet Substudy
Arteriosclerosis, Thrombosis, and Vascular Biology.
43(2)
[DOI] 10.1161/atvbaha.122.318614.
2023
Impact of evolocumab on the pharmacodynamic profiles of clopidogrel in patients with atherosclerotic cardiovascular disease: a randomised, double-blind, placebo-controlled study.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
18(15):1254-1265
[DOI] 10.4244/EIJ-D-22-00719.
[PMID] 36602868.
2023
Influence of body weight and body mass index on the chronic pharmacokinetic and pharmacodynamic responses to clinically available doses of ticagrelor in patients with chronic coronary syndromes.
Vascular pharmacology.
149
[DOI] 10.1016/j.vph.2023.107145.
[PMID] 36720377.
2023
Long-Term Clopidogrel Monotherapy After Percutaneous Coronary Intervention: Will the Pupil Surpass the Master?
Journal of the American College of Cardiology.
82(16):1579-1582
[DOI] 10.1016/j.jacc.2023.08.035.
[PMID] 37821167.
2023
Long-Term P2Y
12
Inhibitor or Aspirin as Single Antiplatelet Therapy in Patients With Previous Percutaneous Coronary Intervention
Circulation.
147(2):118-121
[DOI] 10.1161/circulationaha.122.063004.
2023
Monitoring antiplatelet therapy: where are we now?
Journal of cardiovascular medicine (Hagerstown, Md.).
24(Suppl 1):e24-e35
[DOI] 10.2459/JCM.0000000000001406.
[PMID] 36729588.
2023
Oral P2Y12 inhibiting therapy in patients with acute coronary syndrome: finding the sweet spot
European Heart Journal.
44(3):236-236
[DOI] 10.1093/eurheartj/ehac601.
2023
P2Y12 Inhibitor Monotherapy Combined With Colchicine Following PCI in ACS Patients: The MACT Pilot Study.
JACC. Cardiovascular interventions.
16(15):1845-1855
[DOI] 10.1016/j.jcin.2023.05.035.
[PMID] 37587591.
2023
P2Y12 Inhibitor Monotherapy or Dual Antiplatelet Therapy After Complex Percutaneous Coronary Interventions.
Journal of the American College of Cardiology.
81(6):537-552
[DOI] 10.1016/j.jacc.2022.11.041.
[PMID] 36754514.
2023
P2Y12 inhibitor monotherapy versus dual antiplatelet therapy in patients with acute coronary syndromes undergoing coronary stenting: rationale and design of the NEOMINDSET Trial.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
19(4):e323-e329
[DOI] 10.4244/EIJ-D-23-00125.
[PMID] 37306039.
2023
Personalised antiplatelet therapies for coronary artery disease: what the future holds
European Heart Journal.
44(32):3059-3072
[DOI] 10.1093/eurheartj/ehad362.
2023
Revascularization strategies versus optimal medical therapy in chronic coronary syndrome: A network meta-analysis.
International journal of cardiology.
370:58-64
[DOI] 10.1016/j.ijcard.2022.10.023.
[PMID] 36265647.
2023
Reversal and removal of oral antithrombotic drugs in patients with active or perceived imminent bleeding.
European heart journal.
44(20):1780-1794
[DOI] 10.1093/eurheartj/ehad119.
[PMID] 36988155.
2023
Role of platelet function and genetic testing in patients undergoing percutaneous coronary intervention.
Trends in cardiovascular medicine.
33(3):133-138
[DOI] 10.1016/j.tcm.2021.12.007.
[PMID] 34936903.
2023
Sex-stratified differences in early antithrombotic treatment response in patients presenting with ST-segment elevation myocardial infarction.
American heart journal.
258:17-26
[DOI] 10.1016/j.ahj.2022.12.013.
[PMID] 36596332.
2023
Switching From Cangrelor to Prasugrel in Patients Undergoing Percutaneous Coronary Intervention: The Switching Antiplatelet-6 (SWAP-6) Study.
JACC. Cardiovascular interventions.
16(20):2528-2539
[DOI] 10.1016/j.jcin.2023.08.009.
[PMID] 37609698.
2023
The effect of a Prasugrel- vs. a Ticagrelor-based strategy on total ischaemic and bleeding events in patients with acute coronary syndromes.
European heart journal. Cardiovascular pharmacotherapy.
9(3):231-239
[DOI] 10.1093/ehjcvp/pvac067.
[PMID] 36434779.
2023
The evaluation and management of coagulopathies in the intensive therapy units.
European heart journal. Acute cardiovascular care.
12(6):399-407
[DOI] 10.1093/ehjacc/zuad051.
[PMID] 37172025.
2023
Ticagrelor Enhances the Cardioprotective Effects of Ischemic Preconditioning in Stable Patients Undergoing Percutaneous Coronary Intervention: the TAPER-S Randomized Study.
European heart journal. Cardiovascular pharmacotherapy.
[DOI] 10.1093/ehjcvp/pvad092.
[PMID] 38006237.
2023
Ticagrelor or prasugrel in patients with acute coronary syndrome with off-hour versus on-hour presentation: a subgroup analysis of the ISAR-REACT 5 trial.
Clinical research in cardiology : official journal of the German Cardiac Society.
112(4):518-528
[DOI] 10.1007/s00392-022-02040-z.
[PMID] 35789430.
2023
Ticagrelor with or without aspirin in high-risk patients with anaemia undergoing percutaneous coronary intervention: a subgroup analysis of the TWILIGHT trial.
European heart journal. Cardiovascular pharmacotherapy.
9(4):328-336
[DOI] 10.1093/ehjcvp/pvad006.
[PMID] 36649694.
2023
Timing, Selection, Modulation, and Duration of P2Y12 Inhibitors for Patients With Acute Coronary Syndromes Undergoing PCI.
JACC. Cardiovascular interventions.
16(1):1-18
[DOI] 10.1016/j.jcin.2022.10.023.
[PMID] 36599574.
2023
Within and beyond 12-month efficacy and safety of antithrombotic strategies in patients with established coronary artery disease: two companion network meta-analyses of the 2022 joint clinical consensus statement of the European Association of Percutaneous Cardiovascular Interventions (EAPCI), European Association for Acute CardioVascular Care (ACVC), and European Association of Preventive Cardiology (EAPC).
European heart journal. Cardiovascular pharmacotherapy.
9(3):271-290
[DOI] 10.1093/ehjcvp/pvad016.
[PMID] 36869784.
2022
CYP2C19
Genotype‐Guided Antiplatelet Therapy After Percutaneous Coronary Intervention in Diverse Clinical Settings
Journal of the American Heart Association.
11(4)
[DOI] 10.1161/jaha.121.024159.
2022
A Comprehensive Review of the Pleiotropic Effects of Ticagrelor.
Cardiovascular drugs and therapy.
[DOI] 10.1007/s10557-022-07373-5.
[PMID] 36001200.
2022
ABCD‐GENE Score and Clinical Outcomes Following Percutaneous Coronary Intervention: Insights from the TAILOR‐PCI Trial
Journal of the American Heart Association.
11(4)
[DOI] 10.1161/jaha.121.024156.
2022
Antiplatelet therapy after percutaneous coronary intervention.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
17(17):e1371-e1396
[DOI] 10.4244/EIJ-D-21-00904.
[PMID] 35354550.
2022
Approaches to de-escalation of antiplatelet treatment in stabilized post-myocardial infarction patients with high ischemic risk
Expert Review of Cardiovascular Therapy.
20(10):839-849
[DOI] 10.1080/14779072.2022.2137492.
2022
Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis.
JAMA.
328(6):554-562
[DOI] 10.1001/jama.2022.11966.
[PMID] 35943473.
2022
Bentracimab for Ticagrelor Reversal in Patients Undergoing Urgent Surgery.
NEJM evidence.
1(3)
[DOI] 10.1056/EVIDoa2100047.
[PMID] 38319214.
2022
Bleeding and Ischemic Outcomes With Ticagrelor Monotherapy According to Body Mass Index.
JACC. Cardiovascular interventions.
15(19):1948-1960
[DOI] 10.1016/j.jcin.2022.07.039.
[PMID] 36202563.
2022
Bleeding avoidance strategies in percutaneous coronary intervention
Nature Reviews Cardiology.
19(2):117-132
[DOI] 10.1038/s41569-021-00598-1.
2022
Body mass index and efficacy and safety of ticagrelor versus prasugrel in patients with acute coronary syndromes.
Revista espanola de cardiologia (English ed.).
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Genetics in medicine : official journal of the American College of Medical Genetics.
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2020
Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel: The ABCD-GENE Score.
JACC. Cardiovascular interventions.
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2020
Downstream or upstream administration of P2Y12 receptor blockers in non-ST elevated acute coronary syndromes: study protocol for a randomized controlled trial.
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Dual Pathway Inhibition for Vascular Protection in Patients with Atherosclerotic Disease: Rationale and Review of the Evidence.
Thrombosis and haemostasis.
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2020
Dual-pathway inhibition for secondary and tertiary antithrombotic prevention in cardiovascular disease
Nature Reviews Cardiology.
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2020
Duration of Dual Antiplatelet Therapy After PCI: How Short Can We Go?
JACC. Cardiovascular interventions.
13(19):2263-2265
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2020
Editorial commentary: Evolving paradigms in antithrombotic therapy for patients with coronary artery disease undergoing percutaneous coronary intervention.
Trends in cardiovascular medicine.
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Effect of Prehospital Crushed Prasugrel Tablets in Patients With ST-Segment–Elevation Myocardial Infarction Planned for Primary Percutaneous Coronary Intervention
Circulation.
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2020
Effects of Edoxaban on the Cellular and Protein Phase of Coagulation in Patients with Coronary Artery Disease on Dual Antiplatelet Therapy with Aspirin and Clopidogrel: Results of the EDOX-APT Study.
Thrombosis and haemostasis.
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2020
Evaluating the extent of reusability of CYP2C19 genotype data among patients genotyped for antiplatelet therapy selection.
Genetics in medicine : official journal of the American College of Medical Genetics.
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2020
Extended antiplatelet therapy with clopidogrel alone versus clopidogrel plus aspirin after completion of 9- to 12-month dual antiplatelet therapy for acute coronary syndrome patients with both high bleeding and ischemic risk. Rationale and design of the OPT-BIRISK double-blinded, placebo-controlled randomized trial.
American heart journal.
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2020
Fractional Flow Reserve-Based Coronary Artery Bypass Surgery: Current Evidence and Future Directions.
JACC. Cardiovascular interventions.
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2020
Impact of renal function on clinical outcomes after PCI in ACS and stable CAD patients treated with ticagrelor: a prespecified analysis of the GLOBAL LEADERS randomized clinical trial.
Clinical research in cardiology : official journal of the German Cardiac Society.
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2020
Lipid Management in Patients Presenting With Acute Coronary Syndromes: A Review
Journal of the American Heart Association.
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2020
Long-Term Safety and Efficacy of Durable Polymer Cobalt-Chromium Everolimus-Eluting Stents in Patients at High Bleeding Risk: A Patient-Level Stratified Analysis From Four Postapproval Studies.
Circulation.
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Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery: A Meta-analysis.
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Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention
Circulation.
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2020
Pharmacodynamic Effects of Vorapaxar in Prior Myocardial Infarction Patients Treated With Potent Oral P2Y12Receptor Inhibitors With and Without Aspirin: Results of the VORA‐PRATIC Study
Journal of the American Heart Association.
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2020
Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes.
European heart journal.
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2020
Pooling the Evidence at the Patient Level: End of the Bivalirudin Saga?
Thrombosis and haemostasis.
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Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes: Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing.
JACC. Basic to translational science.
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2020
Radial versus femoral and bivalirudin versus unfractionated heparin in vulnerable patients with acute coronary syndromes.
Revista espanola de cardiologia (English ed.).
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2020
Reply: P2Y12 Inhibitor-Based Monotherapy: Optimal Duration and Ideal Agent.
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2020
Safety and Efficacy of Double Antithrombotic Therapy With Non–Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis
Journal of the American Heart Association.
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2020
Selatogrel, a novel P2Y12 inhibitor: a review of the pharmacology and clinical development.
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2020
Sex-Related Differences in Patients at High Bleeding Risk Undergoing Percutaneous Coronary Intervention: A Patient-Level Pooled Analysis From 4 Postapproval Studies.
Journal of the American Heart Association.
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2020
Ticagrelor alone vs. ticagrelor plus aspirin following percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes: TWILIGHT-ACS
European Heart Journal.
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Ticagrelor monotherapy in patients with concomitant diabetes mellitus and chronic kidney disease: a post hoc analysis of the GLOBAL LEADERS trial.
Cardiovascular diabetology.
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2020
Ticagrelor monotherapy in patients with diabetes mellitus undergoing percutaneous coronary interventions: insights from the TWILIGHT trial.
Cardiovascular research.
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Ticagrelor or Clopidogrel in Elderly Patients With Myocardial Infarction
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2020
Ticagrelor or Prasugrel for Platelet Inhibition in Acute Coronary Syndrome Patients: The ISAR-REACT 5 Trial.
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2020
Ticagrelor or Prasugrel in Patients With Acute Coronary Syndromes and Diabetes Mellitus.
JACC. Cardiovascular interventions.
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2020
Ticagrelor or Prasugrel in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes.
Journal of the American College of Cardiology.
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2020
Ticagrelor or Prasugrel in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Circulation.
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2020
Ticagrelor With or Without Aspirin After Complex PCI.
Journal of the American College of Cardiology.
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2020
Ticagrelor With or Without Aspirin After PCI: The TWILIGHT Platelet Substudy.
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2020
Ticagrelor With or Without Aspirin in High-Risk Patients With Diabetes Mellitus Undergoing Percutaneous Coronary Intervention.
Journal of the American College of Cardiology.
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2020
Timing of Oral P2Y12 Inhibitor Administration in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome.
Journal of the American College of Cardiology.
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2020
Trial Design Principles for Patients at High Bleeding Risk Undergoing PCI: JACC Scientific Expert Panel.
Journal of the American College of Cardiology.
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2020
Validation of the Academic Research Consortium High Bleeding Risk Definition in Contemporary PCI Patients.
Journal of the American College of Cardiology.
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2020
When Less Becomes More: Insights on the Pharmacodynamic Effects of Aspirin Withdrawal in Patients With Potent Platelet P2Y
12
Inhibition Induced by Ticagrelor
Journal of the American Heart Association.
9(24)
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2019
Anticoagulation, the Unknown of the Antithrombotic Equation After Stenting of an Acute Coronary Syndrome.
Journal of the American College of Cardiology.
73(7):775-778
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2019
Aspirin for the primary prevention of cardiovascular disease: latest evidence.
Expert review of cardiovascular therapy.
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2019
Aspirin-Dependent Effects on Purinergic P2Y1 Receptor Expression.
Thrombosis and haemostasis.
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2019
Atrial fibrillation, with ACS and PCI: walking a tightrope.
European heart journal.
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2019
Benefit and Risks of Aspirin in Addition to Ticagrelor in Acute Coronary Syndromes: A Post Hoc Analysis of the Randomized GLOBAL LEADERS Trial.
JAMA cardiology.
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2019
Bleeding after antiplatelet therapy for the treatment of acute coronary syndromes: a review of the evidence and evolving paradigms.
Expert opinion on drug safety.
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2019
De-escalation from ticagrelor to clopidogrel in acute coronary syndrome patients: a systematic review and meta-analysis.
Journal of thrombosis and thrombolysis.
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2019
De-escalation of oral P2Y12 inhibitors guided by platelet function testing in ACS patients undergoing PCI: impact of diabetes mellitus.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
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2019
Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention.
Circulation.
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2019
Defining high bleeding risk in patients undergoing percutaneous coronary intervention: a consensus document from the Academic Research Consortium for High Bleeding Risk.
European heart journal.
40(31):2632-2653
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2019
Dual antithrombotic therapy for atrial fibrillation and PCI.
Lancet (London, England).
394(10206):1300-1302
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2019
Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.
JACC. Cardiovascular interventions.
12(16):1538-1549
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2019
Emergency Consent: Patients’ and Surrogates’ Perspectives on Consent for Clinical Trials in Acute Stroke and Myocardial Infarction.
Journal of the American Heart Association.
8(2)
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2019
Evolving paradigms in antithrombotic therapy for anticoagulated patients undergoing coronary stenting
Therapeutic Advances in Cardiovascular Disease.
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2019
Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y12 Receptor Antagonist Effects in Patients With Acute Coronary Syndromes: Insights From the PLATO Trial.
Journal of the American Heart Association.
8(6)
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2019
Intravenous antiplatelet therapies (glycoprotein IIb/IIIa receptor inhibitors and cangrelor) in percutaneous coronary intervention: from pharmacology to indications for clinical use
Therapeutic Advances in Cardiovascular Disease.
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2019
Management of Antithrombotic Therapy in Atrial Fibrillation Patients Undergoing PCI: JACC State-of-the-Art Review.
Journal of the American College of Cardiology.
74(1):83-99
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2019
Oral Anticoagulation After TAVR in Patients With Atrial Fibrillation: The Certainty of Uncertainty.
JACC. Cardiovascular interventions.
12(16):1577-1579
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2019
Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus: Results of the OPTIMUS-5 Study.
JACC. Basic to translational science.
4(7):763-775
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2019
Pharmacodynamics During Transition Between Platelet P2Y12 Inhibiting Therapies.
Interventional cardiology clinics.
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2019
Pharmacokinetic-pharmacodynamic modelling of platelet response to ticagrelor in stable coronary artery disease and prior myocardial infarction patients.
British journal of clinical pharmacology.
85(2):413-421
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2019
Pharmacokinetic/pharmacodynamic assessment of a novel, pharmaceutical lipid–aspirin complex: results of a randomized, crossover, bioequivalence study
Journal of Thrombosis and Thrombolysis.
48(4):554-562
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2019
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
Circulation.
139(14):1661-1670
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2019
Pre-Treatment With Oral P2Y12 Inhibitors in Acute Coronary Syndromes Without ST-Segment Elevation: The Saga Continues.
Journal of the American College of Cardiology.
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2019
Reply: Platelet Function and Genetic Testing in Patients Receiving Oral Anticoagulation and Antiplatelet Treatment: An Area of Unmet Need.
JACC. Cardiovascular interventions.
12(18):1868-1869
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2019
Reply: Therapeutic Window of P2Y12 Inhibition: Should the Current Limits Be Modified?
JACC. Cardiovascular interventions.
12(23):2434-2435
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2019
Role of oral anticoagulant therapy for secondary prevention in patients with stable atherothrombotic disease manifestations
Therapeutic Advances in Hematology.
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2019
Standardized classification and framework for reporting, interpreting, and analysing medication non-adherence in cardiovascular clinical trials: a consensus report from the Non-adherence Academic Research Consortium (NARC).
European heart journal.
40(25):2070-2085
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2019
Stroke After Coronary Artery Bypass Grafting and Percutaneous Coronary Intervention: Incidence, Pathogenesis, and Outcomes.
Journal of the American Heart Association.
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2019
Systematic Evaluation of the Robustness of the Evidence Supporting Current Guidelines on Myocardial Revascularization Using the Fragility Index.
Circulation. Cardiovascular quality and outcomes.
12(12)
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2019
Tailoring Antiplatelet Therapy in Patients Undergoing Transcatheter Aortic Valve Replacement: Navigating the Unknown.
JACC. Cardiovascular interventions.
12(1):33-37
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2019
Tailoring P2Y12 Inhibiting Therapy in Elderly Patients With Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
Journal of the American Heart Association.
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2019
The Conundrum Surrounding Racial Differences on Ischaemic and Bleeding Risk with Dual Anti-Platelet Therapy.
Thrombosis and haemostasis.
119(1):9-13
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2019
The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction.
American heart journal.
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Three-Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta-Analysis.
Journal of the American Heart Association.
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2019
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes.
The New England journal of medicine.
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2019
Ticagrelor with or without Aspirin in High-Risk Patients after PCI.
The New England journal of medicine.
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Tug of War Between Dual and Triple Antithrombotic Therapy in Atrial Fibrillation/PCI Patients With CKD.
JACC. Cardiovascular interventions.
12(16):1562-1565
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2019
Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.
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2018
A Multidisciplinary Approach on the Perioperative Antithrombotic Management of Patients With Coronary Stents Undergoing Surgery: Surgery After Stenting 2.
JACC. Cardiovascular interventions.
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2018
ACC/AHA Versus ESC Guidelines on Dual Antiplatelet Therapy: JACC Guideline Comparison.
Journal of the American College of Cardiology.
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2018
Antithrombotic Therapy in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Undergoing Percutaneous Coronary Intervention: A North American Perspective-2018 Update.
Circulation.
138(5):527-536
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2018
Aspirin for primary prevention of cardiovascular disease.
Lancet (London, England).
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2018
Aspirin-free strategies in cardiovascular disease and cardioembolic stroke prevention.
Nature reviews. Cardiology.
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Canakinumab for secondary prevention of atherosclerotic disease.
Expert opinion on biological therapy.
18(2):215-220
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2018
Cardiorenal Safety of OTC Analgesics.
Journal of cardiovascular pharmacology and therapeutics.
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2018
Cigarette smoking reduces platelet reactivity independently of clopidogrel treatment in patients with non-ST elevation acute coronary syndromes.
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2018
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention.
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2018
CSL112, a reconstituted, infusible, plasma-derived apolipoprotein A-I: safety and tolerability profiles and implications for management in patients with myocardial infarction.
Expert opinion on investigational drugs.
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2018
Diabetes and antiplatelet therapy: from bench to bedside.
Cardiovascular diagnosis and therapy.
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2018
Effect of a Contrast Modulation System on Contrast Media Use and the Rate of Acute Kidney Injury After Coronary Angiography.
JACC. Cardiovascular interventions.
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2018
Evolution of Coronary Stent Technology and Implications for Duration of Dual Antiplatelet Therapy.
Progress in cardiovascular diseases.
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2018
Gender differences on benefits and risks associated with oral antithrombotic medications for coronary artery disease.
Expert opinion on drug safety.
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2018
High on-treatment platelet reactivity and outcome in elderly with non ST-segment elevation acute coronary syndrome – Insight from the GEPRESS study.
International journal of cardiology.
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2018
Impact of Multidrug Resistance Protein-4 Inhibitors on Modulating Platelet Function and High on-Aspirin Treatment Platelet Reactivity.
Thrombosis and haemostasis.
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2018
Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition).
Circulation. Cardiovascular interventions.
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2018
Inhibitory mechanisms of very low-dose rivaroxaban in non-ST-elevation myocardial infarction.
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2018
Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy.
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P2Y12-ADP Receptor Blockade in Chronic Kidney Disease Patients With Acute Coronary Syndromes.
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Clinical Pharmacology and Cardiovascular Safety of Naproxen.
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Impact of gastric acid-suppressing therapies on platelet reactivity in patients with coronary artery disease treated with clopidogrel: results of a pharmacodynamic study.
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Assessment of microcirculatory remodeling with intracoronary flow velocity and pressure measurements: validation with endomyocardial sampling in cardiac allografts.
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Clopidogrel-Induced Antiplatelet Effect Assessment By Flow Cytometry and Point-Of-Care Based Assays: Correlation Between Vasp and Verifynow P2Y(12) Testing
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Comparison of Prasugel With Clopidogrel On Platelet Function in Coronary Artery Disease Patients With Type 2 Diabetes Mellitus – Third Optimizing Anti-Platelet Therapy in Diabetes Mellitus (Optimus-3)
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Decrease in Poor Responders On Switching From Clopidogrel To Prasugrel: Results From the Switching Anti Platelet (Swap) Study
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120:S1027-S1028
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Diabetes mellitus: a prothrombotic state implications for outcomes after coronary revascularization.
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Evaluation of a Modified Light Transmittance Aggregometry Protocol To Assess P2Y(12) Blockade Induced By Clopidogrel
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Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: results from the double-blind, prospective, randomized Tailoring Treatment with Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel study.
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2009
Maintenance Treatment With Ticagrelor Yields Greater and More Consistent Inhibition of Platelet Function Compared To Clopidogrel in Patients With Acute Coronary Syndromes: Results From the Plato Platelet Substudy
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More Rapid and Consistent Inhibition of Platelet Aggregation Is Achieved By Loading With Ticagrelor Compared To Clopidogrel in Patients With Acute Coronary Syndromes: Results From the Plato Platelet Substudy
Circulation.
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New antiplatelet agents.
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Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial.
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Platelet Function in Diabetes Mellitus: Observations From the Principle-Timi 44 Trial
Circulation.
120:S548-S549
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Strategies for drug-eluting stent treatment of bifurcation coronary artery disease in the United States: insights from the e-Cypher S.T.L.L.R.trial.
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2008
A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study.
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A systematic review of outcomes in patients with staged carotid artery stenting and coronary artery bypass graft surgery.
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Analysis of Thrombotic Profiles in Patients With End Stage Renal Disease Undergoing Hemodialysis
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56:415-416
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Angiographic and 3D intravascular ultrasound assessment of overlapping bare metal stent and three different formulations of drug-eluting stents in patients with diabetes mellitus.
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Assessing the current role of platelet function testing.
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Assessment of potential relationship between wall shear stress and arterial wall response after bare metal stent and sirolimus-eluting stent implantation in patients with diabetes mellitus.
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Functional effects of high clopidogrel maintenance dosing in patients with inadequate platelet inhibition on standard dose treatment.
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Pharmacodynamic Assessment of Platelet Inhibition By Prasugrel Versus Clopidogrel in the Triton-Timi 38 Trial
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Prasugrel: a Novel Platelet Adp P2Y(12) Receptor Antagonist. a Review On Its Mechanism of Action and Clinical Development
Expert Opinion on Pharmacotherapy.
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Prasugrel: a novel platelet ADP P2Y12 receptor antagonist. A review on its mechanism of action and clinical development.
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Prognostic significance of troponin T elevation in patients without chest pain.
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Short- or long-term outcomes of coronary artery aneurysms occurring after directional coronary atherectomy.
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Tailoring treatment with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel (3T/2R). Rationale for the study and protocol design.
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The problem of persistent platelet activation in acute coronary syndromes and following percutaneous coronary intervention.
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Anatomical and physiologic assessments in patients with small coronary artery disease: final results of the Physiologic and Anatomical Evaluation Prior to and After Stent Implantation in Small Coronary Vessels (PHANTOM) trial.
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Effects of escalating doses of tirofiban on platelet aggregation and major receptor expression in diabetic patients: hitting the TARGET in the TENACITY trial?
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Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study.
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“Head-to-head comparison between sirolimus-eluting and paclitaxel-eluting stents in patients with complex coronary artery disease: an intravascular ultrasound study”.
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[Efficacy of sirolimus-eluting stent implantation in diabetic patients with very small vessels (< or = 2.25 mm). Insights from the DIABETES trial].
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2004
Late stent thrombosis (> 1 year) following clopidogrel withdrawal after brachytherapy treatment: need to assess aspirin resistance?
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
62(1):39-42
[PMID] 15103601.
2004
PlA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
15(1):89-93
[PMID] 15166949.
2004
Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted?
The Journal of invasive cardiology.
16(4):169-74
[PMID] 15152138.
2004
Saphenous vein graft disease.
Minerva cardioangiologica.
52(5):379-90
[PMID] 15514573.
2003
[Past, present, and future of intracoronary brachytherapy].
Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology.
4(10):794-806
[PMID] 14664291.
2003
Acute stent thrombosis after early withdrawal of platelet glycoprotein IIb/IIIa antagonists: potential rebound prothrombotic effect?
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
58(4):481-4
[PMID] 12652499.
2003
Antibody response to chlamydial heat shock protein 60 is strongly associated with acute coronary syndromes.
Circulation.
107(24):3015-7
[PMID] 12796125.
2003
Combined role of the Lewis antigenic system, Chlamydia pneumoniae, and C-reactive protein in unstable angina.
Journal of the American College of Cardiology.
41(4):546-50
[PMID] 12598063.
2003
Intracoronary brachytherapy following drug-eluting stent failure. It’s still not time to hang up the spikes!
Cardiovascular radiation medicine.
4(4):171-5
[PMID] 15321053.
2002
Risk of myocardial infarction and angina in patients with severe peripheral vascular disease: predictive role of C-reactive protein.
Circulation.
105(7):800-3
[PMID] 11854118.
2002
Role of myocardial perfusion imaging after coronary revascularization in symptom-free patients: are low-risk patients really low?
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
9(5):550-3
[PMID] 12360136.
2001
Current role of lung scintigraphy in pulmonary embolism.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR).
45(4):294-301
[PMID] 11893966.
2001
Enhanced response of blood monocytes to in vitro lipopolysaccharide-challenge in patients with recurrent unstable angina.
Circulation.
103(18):2236-41
[PMID] 11342470.
2000
Inflammation and acute coronary syndromes.
Herz.
25(2):108-12
[PMID] 10829249.
1999
In vitro hyperreactivity to lipopolysaccharide in patients with history of unstable angina is not associated with seropositivity for Cytomegalovirus, Helicobacter pylori and Chlamydia pneumoniae.
Cardiologia (Rome, Italy).
44(4):377-80
[PMID] 10371790.
1989
The effect of T-2 toxin on active sodium transport across frog skin in the presence of ADH and amphotericin B.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.
93(1):33-6
[PMID] 2567225.
1974
The nature of emergency room follow-up care.
Journal of the American Medical Women's Association (1972).
29(12):547-51
[PMID] 4374471.
Grants
Mar 2024
ACTIVE
A phase III, double-blind, randomized placebo-controlled study to evaluate the effects of dalcetrapib on cardiovascular (CV) risk in a genetically defined population with a recent Acute Coronary Syndrome (ACS)
Role: Principal Investigator
Funding: DALCOR PHARMACEUTICALS
Oct 2023
ACTIVE
A randomized, placebo-controlled, parallel-group, investigator- and participant-blinded Phase 2a study to investigate the efficacy, safety, and tolerability of DFV890 for inflammatory marker reduction in adult participants with coronary heart disease and elevated hsCRP
Role: Principal Investigator
Funding: NOVARTIS PHARMACEUTICALS CORP
Jul 2023
ACTIVE
Medtronic Electrophysiology Fellowship Grant 2024
Role: Other
Funding: MEDTRONIC INC
Apr 2022
ACTIVE
Assessment of Individual Risk of Cardiovascular Events by Platelet FcGammaRIIa
Role: Principal Investigator
Funding: PROLOCOR
Nov 2021
ACTIVE
A Study of Contrast-induced Acute Kidney Injury Prediction Using the RENISCHEM L-FABP Assay at the Point-of-Care (SAKURA-POC)
Role: Principal Investigator
Funding: HIKARI DX
Jan 2021
– Jan 2021
UFF Scott R. MacKenzie Foundation Grant
Role: Principal Investigator
Funding: UF FOUNDATION
via SCOTT R MACKENZIE FOUNDATION
Nov 2020
– Nov 2025
Impact of Timing of Pharmacodynamic Assessments on Measures of Platelet Reactivity in Patients Undergoing Percutaneous Coronary Intervention Treated with Cangrelor
Role: Principal Investigator
Funding: CHIESI USA
Oct 2020
– Oct 2021
Comparison of the VerifyNow? Aspirin Test and PRUTest? Platelet Reactivity Tests with Investigational Reagent to Reagents Registered in Japan
Role: Principal Investigator
Funding: ACCRIVA DIAGNOSTICS
Jul 2020
ACTIVE
Precision antiplatelet therapy after percutaneous coronary intervention
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2020
– Aug 2021
ACTIV-4 Infected Outpatient Study
Role: Project Manager
Funding: UNIV OF PITTSBURGH
via NATL INST OF HLTH NHLBI
Jun 2020
– Sep 2022
Evaluating Fitness-for-use of Electronic Health Records in Clinical Research
Role: Principal Investigator
Funding: DUKE UNIVERSITY
via US FOOD AND DRUG ADMN
Jan 2020
– Dec 2021
UFF Scott R. MacKenzie Foundation Grant
Role: Principal Investigator
Funding: UF FOUNDATION
via SCOTT R MACKENZIE FOUNDATION
Nov 2019
ACTIVE
Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry
Role: Principal Investigator
Funding: DUKE UNIVERSITY
via CHIESI USA
Aug 2019
ACTIVE
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke.
Role: Principal Investigator
Funding: AMGEN INC
Aug 2019
ACTIVE
Early Feasibility Study of the Edwards Transcatheter Atrial Shunt System
Role: Principal Investigator
Funding: EDWARDS LIFESCIENCES
Aug 2019
ACTIVE
Switching from standard of care dual antiplatelet treatment (DAPT) regimens with aspirin plus a P2Y12 inhibitor to dual pathway inhibition (DPI) with low-dose rivaroxaban in adjunct to aspirin in patients with coronary artery disease: The Switching Anti-Platelet and Anti-Coagulant Therapy (SWAP-AC
Role: Principal Investigator
Funding: JANSSEN SCIENTIFIC AFFAIRS
Jun 2019
ACTIVE
Management of Antiplatelet Regimen During Surgical Procedures
(MARS Registry)
Role: Principal Investigator
Funding: UNIV OF TEXAS SW MEDICAL CENTER
via CHIESI USA
Apr 2019
– Apr 2024
Cirquest HF study
Role: Principal Investigator
Funding: MLM MEDICAL LABS, LLC
Nov 2018
– Mar 2021
Pharmacodynamic effects of low-dose rivaroxaban in combination with antiplatelet therapies in patients with coronary and peripheral artery disease manifestations
Role: Principal Investigator
Funding: JANSSEN SCIENTIFIC AFFAIRS
Nov 2018
ACTIVE
Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts (ECLIPSE)
Role: Principal Investigator
Funding: CARDIOVASCULAR SYSTEMS INC
Sep 2018
ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Mar 2018
ACTIVE
A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group
Study to Investigate the Efficacy and Safety of CSL112
in Subjects with Acute Coronary Syndrome
Role: Principal Investigator
Funding: CSL BEHRING
Jan 2018
– Aug 2021
A Randomized Comparison of Platelet Inhibition Using a Low Maintenance Dose Ticagrelor Regimen versus Standard Dose Clopidogrel in Diabetes Mellitus Patients without Prior Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention: The OPTIMUS (Optimizing Antiplatelet Therapy in Diabetes Mellitus)-6 Study
Role: Principal Investigator
Funding: ASTRAZENECA
Dec 2017
– Dec 2022
A multi-center, double-blind, randomized, placebo-controlled study to assess the pharmacodynamics, pharmacokinetics, tolerability, and safety of a single subcutaneous injection of ACT-246475 in adults with stable coronary artery disease
Role: Principal Investigator
Funding: IDORSIA PHARMACEUTICAL LTD
via FORTREA
Dec 2017
– Dec 2022
Pharmacodynamic evaluation of switching from ticagrelor to clopidogrel in patients with coronary artery disease
Role: Principal Investigator
Funding: SANOFI US SERVICES
Nov 2017
– Dec 2019
UFF Scott R. MacKenzie Foundation Grant # 170009
Role: Principal Investigator
Funding: UF FOUNDATION
via SCOTT R MACKENZIE FOUNDATION
Jun 2017
– Jun 2022
Platelet Inhibition with CANgrelor and Crushed TICagrelor in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention:
The CANTIC Study
Role: Principal Investigator
Funding: CHIESI FARMACEUTICI
May 2017
– Jun 2022
Impact of the PCSK9 Inhibitor Evolocumab on the Pharmacodynamic Effects of Clopidogrel in Patients with Atherosclerotic Cardiovascular Disease and
High On-Treatment Platelet Reactivity
Role: Principal Investigator
Funding: AMGEN INC
Mar 2017
– Mar 2022
A PROSPECTIVE STUDY OF THE BIOFREEDOMTM BIOLIMUS A9TM DRUG COATED STENT IN PATIENTS AT HIGH RISK FOR BLEEDING
Role: Principal Investigator
Funding: BIOSENSORS RES USA INC
Feb 2017
– Apr 2022
A multicenter, randomized, double-blind, double dummy, parallel group, active-controlled 8-week study to evaluate the effect of sacubitril and valsartan (LCZ696) versus enalapril on changes in NT-proBNP and safety and tolerability of in-hospital initiation of LCZ696 compared to enalapril in HFrEF patients who have been stabilized following hospitalization for acute decompensated heart failure (ADHF).
Role: Principal Investigator
Funding: NOVARTIS PHARMACEUTICALS CORP
Jan 2017
– Dec 2017
UFF Scott R. MacKenzie Foundation Grant # 160009
Role: Principal Investigator
Funding: UF FOUNDATION
via SCOTT R MACKENZIE FOUNDATION
Oct 2016
– Dec 2016
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 4 Study to Assess the Effect of Naltrexone Hydrochloride and Bupropion Hydrochloride Extended Release Combination on the Occurrence of Major Adverse Cardiovascular Events in Overweight and Obese Subjects with Cardiovascular Disease
Role: Principal Investigator
Funding: TAKEDA DEVELOPMENT CENTER AMERICAS INC
Aug 2016
– Aug 2026
A Phase 2, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group, Study to Investigate the Safety and Tolerability of Multiple Dose Administration of CSL112 in Subjects with Moderate Renal Impairment and Acute Myocardial Infarction
Role: Principal Investigator
Funding: CSL Behring Research
Jul 2016
– Jul 2021
A Study to Evaluate the Safety & Efficacy RenalGuard? System of the When Compared with Standard Care in the Prevention of Contrast Induced Nephropathy in the Setting of a Catheterization Laboratory
Role: Principal Investigator
Funding: PLC MEDICAL SYSTEMS INC
Jun 2016
– Jun 2017
VFN-CSS-16-0003 – VerifyNow PRUTest Cardiovascular Population Expected Values On-Drug Study
Role: Principal Investigator
Funding: ACCRIVA DIAGNOSTICS
Apr 2016
– Jul 2023
COBRA PZF STENTING TO REDUCE THE DURATION OF TRIPLE THERAPY IN PATIENTS TREATED WITH ORAL ANTICOAGULATION UNDERGOING..
Role: Principal Investigator
Funding: CELONOVA BIOSCIENCES INC
Feb 2016
– Feb 2019
EFFECT OF D-ALLULOSE INGESTION ON THE GLUCOSE AND INSULIN RESPONSE TO A STANDARDIZED ORAL SUCROSE LOAD
Role: Principal Investigator
Funding: MATSUTANI CHEMICAL INDUSTRY CO LTD
Jan 2016
– Jan 2021
IMPACT OF CHRONIC KIDNEY DISEASE ON THE PHARMACODYNAMIC AND PHARMACOKINETIC EFFECTS OF TICAGRELOR IN PATIENTS WITH……
Role: Principal Investigator
Funding: ASTRAZENECA
Dec 2015
– Dec 2021
Adjunctive Vorapaxar Therapy in Patients with Prior Myocardial Infarction Treated with New Generation P2Y12 Receptor Inhibitors Prasugrel and Ticagrelor (VORA-PRATIC): A Prospective, Randomized, Pharmacodynamic Study
Role: Principal Investigator
Funding: MERCK SHARP & DOHME
Dec 2015
– Dec 2020
PHARMACODYNAMIC EFFECTS OF VORAPAXAR AS AN ADD-ON ANTIPLATELET THERAPY IN POST MYOCARDIAL INFARCTION PATIENTS.
Role: Principal Investigator
Funding: ARALEZ PHARMA
Oct 2015
– Apr 2022
TWILIGHT STUDY TICAGRELOR WITH ASPIRIN OR ALONE IN HIGH RISK PATIENTS AFTER CORONARY INTERVENTION
Role: Principal Investigator
Funding: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Oct 2015
– Oct 2018
EFFECTS OF EDOXABAN ON THE CELLULAR AND PROTEIN PHASE OF COAGULATION IN PATIENTS WITH CORONARY ARTERY DISEASE ON DUAL
Role: Principal Investigator
Funding: DAIICHI SANKYO
Sep 2015
– Aug 2018
INVESTIGATING TICAGRELOR TREATMENT IN PATIENTS WITH MYOCARDIAL INJURY POST NON-CARDIAC SURGERY
Role: Principal Investigator
Funding: CLEVELAND CLINIC FOU
Aug 2015
– Aug 2018
A PROSPECTIVE RANDOMISED,OPEN LABEL,BLINDED ENDPOINT (PROBE)STUDY TO EVALUATE DUAL ANTITHROMBOTIC THERAPY W/DABIGATRAN..
Role: Principal Investigator
Funding: BOEHRINGER INGELHEIM PHARM INC
May 2015
– May 2018
EFFECT OF THE PERIPHERAL OPIOID RECEPTOR ANTAGONIST METHYLNALTREXONE ON THE PHARMACOKINETIC & PHARMACODYNAMIC..
Role: Principal Investigator
Funding: ASTRAZENECA
Dec 2014
– Dec 2017
A PHASE 2B MULTI-CENTER RANDOMIZED PLACEBO-CONTROLLED DOSE- RANGING STAUDY TO INVESTIGATE THE SAFETY & TOLERABILITY…
Role: Principal Investigator
Funding: DUKE UNIVERSITY
via CSL BEHRING GMBH
Sep 2014
– Sep 2017
PHARMACODYNAMIC & PHARMACOKINETIC PROFILES OF PRASUGREL IN PATIENTS WITH ST ELEVATION MYCOCARDIAL INFARETION….
Role: Principal Investigator
Funding: LILLY USA
Sep 2014
– Sep 2017
AVERT TRIAL
Role: Principal Investigator
Funding: OSPREY MEDICAL, INC
Aug 2014
– Feb 2019
A MULTINATIONAL RANDOMISED DOUBLE-BLIND PLACBO-CONTROLLED TRIAL TO EVALUATE THE EFFECT OF TICAGRELOR 90 MG TWICE….
Role: Principal Investigator
Funding: ASTRAZENECA
Aug 2014
– Aug 2017
A PHASE IV RANDOMIZED MULTI-CENTRE OPEN LABEL COMPARISON OF PLATELET INHIBITION FOLLOWING LOADING DOSES OF TICAGRELOR…
Role: Principal Investigator
Funding: ASTRAZENECA
Jun 2014
– Jun 2022
A RANDOMIZED DBL-BLIND PLACEBO-CONTROLLED PARALLEL-GROUP STUDY TO EVALUATE THE EFFECT OF LONG TERM TREATMENT WITH….
Role: Principal Investigator
Funding: EISAI
Mar 2014
– Mar 2017
CORONARY STENT SYSTWM CLINICAL TRIAL IN SUBJECTS WITH ST ELEVATED MYOCARDIAL INFARCTION (STEMI)
Role: Principal Investigator
Funding: STENTYS
Dec 2013
– Dec 2016
PHARMOCODYNAMIC EFFECTS OF CANGREFOR ON PLATELET P2Y12 RECEPTOR MEDIATED SIGNALING IN TICAGRELOR TREATED PATIENTS
Role: Principal Investigator
Funding: THE MEDICINES COMPANY
Dec 2013
– Dec 2016
A RANDOMIZED, MULTI-CENTER, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO DETERMINE THE EFFECTS OF AMG-145 TREATMENT ON…
Role: Principal Investigator
Funding: AMGEN INC
Nov 2013
– Mar 2017
AN OPEN LABEL RANDOMIZED CONTROLLED MULTICENTER STUDY EXPLORING TWO TREATMENT STRATEGIES OF RIVAROXABAN….
Role: Principal Investigator
Funding: JANSSEN SCIENTIFIC AFFAIRS
Jun 2013
– Jun 2016
PHARMACODYNAMICS PROFILES OF TICAGRELOR IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION…
Role: Principal Investigator
Funding: ASTRAZENECA
Jun 2013
– Sep 2018
Genomic Medicine Implementation: The Personalized Medicine Program
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Jun 2013
– May 2017
A RANDOMISED DOUBLE-BLIND PARALLEL GROUP MULTICENTRE PHASE IIIB STUDY TO COMPARE TICAGRELOR WITH CLOPIDOGREL ….
Role: Principal Investigator
Funding: DUKE UNIVERSITY
via ASTRAZENECA
Mar 2012
– Mar 2018
SUBSTUDY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL GROUP, MULTINATIONAL TRIAL, TO ASSES THE PREVENTION
Role: Principal Investigator
Funding: ASTRAZENECA
Sep 2011
– Jun 2017
GM0615OMIZED DOUBLE BLIND PLACEBO CONTROLLED EVENT DRIVEN TRIAL OF QUARTERLY SUBCUTANEOUS CANAKINUMAB IN THE…………
Role: Principal Investigator
Funding: NOVARTIS PHARMACEUTICALS CORP
Apr 2011
– Apr 2017
RELOAD: IMPACT OF PRASUGREL RE-LOAD ON PLATELET AGGREGATION IN PATIENTS ON CHRONIC PRASUGREL THERAPY
Role: Principal Investigator
Funding: ELI LILLY AND CO
Feb 2010
– Dec 2016
STABILIZATION OF PLAQUES USING DARAPLADIB – A CLINCAL OUTCOMES STUDY OF DARAPLADIB VERSUS PLACEBO IN SUBJECTS FOLLOWING
Role: Principal Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL
via GLAXO SMITHKLINE
Education
Ph.D., Cellular and Molecular Cardiology
2006
·
Catholic University of the Sacred Heart
Cardiovascular Disease Fellowship
2004
·
San Carlos University Hospital
Internal Medicine Residency
2001
·
Catholic University of the Sacred Heart
Doctor of Medicine
1997
·
Catholic University of the Sacred Heart Faculty of Medicine and Surgery
Contact Details
Phones:
- Business:
- (904) 244-2655
Emails:
- Business:
- dominick.angiolillo@jax.ufl.edu
Addresses:
- Business Mailing:
-
655 W 8TH ST, ACC BLDG, 5TH FL
DEPT. OF MEDICINE/DIVISION OF CARDIOLOGY
JACKSONVILLE FL 32209 - Business Street:
-
655 W 8TH ST, ACC BLDG, 5TH FL
DEPT OF MEDICINE/CARDIOLOGY
JACKSONVILLE FL 32209